Project Summary

Stephen F. Traynelis, Ph.D. (Independent Investigator 2000) of Emory University, will evaluate the effect of the selective receptor (PAR1) activating compounds in mice on NMDA receptor current responses. Previous work suggests that activation of protease receptors can increase the activity of NMDA receptors in the brain.  Dysfunction of the NMDA receptor has been implicated in the pathophysiology of schizophrenia. Dr. Traynelis will use sophisticated techniques including whole cell voltage clamp of neurons in the deep layers of the cingulate cortex and subiculum, brain regions potentially relevant to schizophrenia. This work will help to determine the reasons behind the stimulating effect of PAR1 on NMDA receptor function. A better understanding of PAR1's ability to enhance NMDA receptors may suggest opportunities for new medications to address diminished function of the NMDA receptor in schizophrenia.

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia\Neurodegeneration

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