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Sandra Villafuerte, Ph.D. (Young Investigator 2005) of the University of Michigan, plans to perform detailed analysis of genes called serpins, which are associated with extraversion and neuroticism, two traits individuals with bipolar disorder exhibit. In the brain, serine proteases and serpins play a role in neuropeptide processing, regulation of neuronal survival and structural plasticity. In this study, Dr. Villafuerte proposes to understand the relationship among certain gene variants, relevant personality traits and bipolar disorder. Program Area: MOOD DISORDERS\Bipolar\Bipolar I |
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