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 Project Summary  John B. Vincent, Ph.D. (Young Investigator 2004) of Centre for Addiction and Mental Health of the University of Toronto, proposes identifying the genes that are associated with some chromosomal translocations found in certain individuals with autism. Translocations arise when a piece of one chromosome breaks off and is transferred to second chromosome, switching places with a piece from the second chromosome. The position where the break occurs may disrupt a gene crucial to normal development or specific brain function, and thus may lead to impaired development and brain dysfunction seen in autism. Dr. Vincent aims to characterize the genes disrupted at the breakpoints in autism patients and to see if these genes are also affected in other ways in autism patients that do not have the translocation. Program Area: PERVASIVE DEVELOPMENTAL DISORDERS\Autism |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator