Project Summary

Sophia Vinogradov, M.D. (Independent Investigator 2000) of Northern California Institute for Research and Education, aims to design a set of computer-based intensive cognitive training exercises which target key domains of neurocognitive impairment in schizophrenia. In a recent pilot study, a cognitive training program was applied to patients with schizophrenia. These findings suggest that this intervention improved symptom profile, verbal/symbolic memory, and verbal short-term memory. In the present study, Dr. Vinogradov will use this technique to target short-term memory, neuromotor sequencing, and cognitive flexibility. In addition, the symptom profile, quality of life, and neurocognitive performance will be evaluated before and after the intervention.  Finally, the effects of the exercises will be compared to those of a non-specific control task. This work has the potential to improve psychosocial functioning, which is believed to be secondary to neurocognitive dysfunction, in patients with schizophrenia.

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia

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