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Franz X. Vollenweider, M.D. (Independent Investigator 2000) of Psychiatric University Hospital, Zurich, will investigate differences in brain activation patterns underlying prepulse inhibition between first episode schizophrenic patients and healthy controls. Prepulse inhibition (PPI) represents a phenomenon known as sensorimotor gating, the ability to filter sensory inputs. Patients with schizophrenia have a deficit in PPI. Dr. Vollenweider will use positron emission tomography (PET) in combination with a test of PPI, in order to elucidate the neuronal activation abnormalities that underlie PPI dysfunction. In addition, the relationship between antipsychotic medications, PPI deficits, and brain activation patterns, will be explored. This work may eventually lead to an improved ability to characterize subgroups of schizophrenic patients in order to develop more specific treatments. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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