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Project Summary

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Franz X. Vollenweider, M.D. (Independent Investigator 2000) of Psychiatric University Hospital, Zurich, will investigate differences in brain activation patterns underlying prepulse inhibition between first episode schizophrenic patients and healthy controls. Prepulse inhibition (PPI) represents a phenomenon known as sensorimotor gating, the ability to filter sensory inputs. Patients with schizophrenia have a deficit in PPI. Dr. Vollenweider will use positron emission tomography (PET) in combination with a test of PPI, in order to elucidate the neuronal activation abnormalities that underlie PPI dysfunction. In addition, the relationship between antipsychotic medications, PPI deficits, and brain activation patterns, will be explored. This work may eventually lead to an improved ability to characterize subgroups of schizophrenic patients in order to develop more specific treatments.

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia

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Announcements
2008/2009 NARSAD Grant Deadlines:

2008 Independent Investigator application deadline: March 5, 2008

2008 Young Investigator, 2008 Distinguished Investigator and 2008 Staglin Grantees Announced: March, 2008

2008 Distinguished Investigator Earliest Start Date: May 1, 2008

2009 Distinguished Investigator Award application deadline: May 15, 2008

2008 Young Investigator Earliest Start Date: July 1, 2008

2009 Young Investigator Award application deadline: July 25, 2008

2008 Independent Investigator Award Earliest Start Date: September 15, 2008

2008 Staglin Award Earliest Start Date: September 15, 2008

2009 Distinguished Investigator Earliest Start Date: May 1, 2009

2009 Young Investigator Earliest Start Date: July 1, 2009





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