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 Project Summary  Jamie M. Zeitzer, Ph.D. (Young Investigator 2003) of Stanford University, will study the effect of sleep deprivation, as it is known to temporarily relieve depression. However, the depression resumes after a night of sleep, which makes sleep deprivation itself an ineffective treatment. Dr. Zeitzer will investigate the underlying physiological change that causes relief of depressive symptoms, specifically, a disruption in the normal function of hypocretin - a small protein produced by the brain that helps regulate wakefulness and metabolism. The effects of sleep deprivation on hypocretin physiology will be examined in the squirrel monkey. If hypocretin increases are found to be associated with sleep deprivation, this research may lead to new treatments in which the hypocretin system is modulated to help alleviate depression. Program Area: MOOD DISORDERS\Depression (Unipolar)\Pharmacology |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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