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 Project Summary  Xiaoxi Zhuang, Ph.D. (Young Investigator 2002) of University of Chicago, will use a genetic approach to differentiate between the function of two subpopulations of D2 receptors-D2 autoreceptors and D2 heteroreceptors. Dopamine D2 receptors are the major targets of antipsychotic drugs. Dr. Zhuang will create knockout mice of the D2 receptor gene and rescue D2 expression in a tissue-specific and inducible manner. The mice will be valuable in differentiating the functions of D2 autoreceptors and heteroreceptors and will provide insight into the contributions of each D2 receptor subpopulation in mediating the therapeutic vs. unwanted side-effects of treatment with antipsychotic agents. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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