Jonathan A. Javitch, M.D., Ph.D.

Jonathan A. Javitch, M.D., Ph.D.


Lieber Professor of Experimental Therapeutics and Professor of Pharmacology
Center for Molecular Recognition
Columbia University College of Physicians and Surgeons
Director, Division of Molecular Therapeutics
New York State Psychiatric Institute
Director, Lieber Center for Schizophrenia Research
Columbia University Medical Center

Dr. Javitch’s research focuses on the structure, function and regulation of G-protein-coupled receptors (GPCRs) and neurotransmitter transporters, especially the dopamine D2 receptor and dopamine transporter (the targets, respectively, for antipsychotic drugs and psychostimulants). His studies of GPCRs are raising the possibility of a novel approach to drug design and screening. Dr. Javitch’s laboratory is also studying bacterial homologs of neurotransmitter transporters to explicate the mechanisms of sodium-coupled transport and the actions of antidepressant drugs that inhibit transport, as well as the dopamine transporter and dopamine receptors in the fruit fly. They have developed approaches to translate molecular mechanisms and whole-organism behavior using fly genetics.

Dr. Javitch joined Columbia in 1992.

NARSAD Grants: Young Investigator 1990 and 1992, Independent Investigator 2003, Distinguished Investigator 2010