Randy D. Blakely, Ph.D.

Randy D. Blakely, Ph.D.

Joined the Scientific Council in 1999

Allan D. Bass Professor of Pharmacology and Psychiatry
Director, Vanderbilt, NIMH Silvio O. Conte Center for
Neuroscience Research
Vanderbilt University School of Medicine

Dr. Blakely studies brain proteins called neurotransmitter transporters to understand how their structure relates to antidepressant and psychostimulant action and how knowledge of transporter regulation can elucidate mechanisms of brain disease and provide clues to novel therapeutics in mental illness. His laboratory has cloned human and rodent genes that encode multiple neurotransmitter transporters, including those that produce the brain’s norepinephrine and serotonin transporters, the targets of most clinically used antidepressants. Dr. Blakely’s group has discovered several mechanisms by which the brain regulates transporter activity, thereby achieving the proper balance of neurotransmitter signaling, and has identifi ed mutations in norepinephrine, dopamine, and serotonin transporters that are associated with multiple neural disorders, including autism, ADHD and major depression.

Prior to joining the Vanderbilt Center for Molecular Neuroscience, Dr. Blakely taught at Emory University School of Medicine.

NARSAD Grants: Distinguished Investigator 1996 and 2005